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For example, methods according to the present invention include methods of reducing the effects of chemotherapy on normal healthy cells in a patient being treated for cancer or abnormal cell proliferation are disclosed, comprising administering to the patient a therapeutically effective amount of a cell cycle inhibitor; and administering to the patient a therapeutically effective amount of a compound of Formula 1 cheap cialis online canadian pharmacy Preferably, they may be purified by affinity chromatography on an anti VAR2CSA antibody column